LC/MS Applications in Drug Development Hardcover - 2002 - 1st Edition
by Mike S. Lee; Dominic M. Desiderio (Editor); Nico M. Nibbering (Editor)
First line
Current trends in drug development emphasize high-volume approaches to accelerate lead candidate generation and evaluation.
From the rear cover
The premier reference on the cutting-edge technology driving new drug development
Breakthroughs in combinatorial chemistry and molecular biology, as well as an overall industry trend toward accelerated development, mean the rate of sample generation now far exceeds the rate of sample analysis in the pursuit of producing new and better pharmaceuticals. LC/MS is an analytical tool that helps the researcher identify the most promising sample early in the selection process, effectively creating a shortcut to finding new drugs. This book is the first to describe LC/MS applications within the context of drug development, including the discovery, preclinical, clinical, and manufacturing phases.
In addition to the thorough technical analysis of this tool, LC/MS Applications in Drug Development provides perspective on the significant changes in strategies for pharmaceutical analysis. A process overview of drug development from an analytical point of view is provided along with essential data required to successfully bring a drug to market. The incorporation of LC/MS is illustrated from target to product. Chapters pertaining to the discovery process itself include:
* Proteomics
* Glycoprotein Mapping
* Natural Products Dereplication
* Lead Identification Screening
* Open-Access LC/MS
* In Vivo Drug Screening
* In Vitro Drug Screening
Written for both the analytical chemist who uses LC/MS applications and the pharmaceutical scientist who works with the drugs they produce, LC/MS Applications in Drug Development is the premier reference on the subject.
Details
- Title LC/MS Applications in Drug Development
- Author Mike S. Lee; Dominic M. Desiderio (Editor); Nico M. Nibbering (Editor)
- Binding Hardcover
- Edition number 1st
- Edition 1
- Pages 256
- Volumes 1
- Language ENG
- Publisher Wiley-Interscience, NY
- Date March 7, 2002
- Illustrated Yes
- ISBN 9780471405207 / 0471405205
- Weight 1.23 lbs (0.56 kg)
- Dimensions 9.72 x 6.18 x 0.88 in (24.69 x 15.70 x 2.24 cm)
- Library of Congress subjects Mass spectrometry, Drugs - Analysis
- Library of Congress Catalog Number 2001058147
- Dewey Decimal Code 615.19
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