Fertilization of rabbit ova in vitro in Nature 184, 1959, pp. 466-467

London: Macmillan, 1959. 1st Edition. HANDSOMELY BOUND FIRST EDITION OF THE FIRST REPORT OF IN-VITRO FERTILIZATION OF AN ANIMAL.

The definitive solution of the problem of in vitro fertilization of the mammalian egg and the first report of a in-vitro fertiliation in an animal was provided by the Chinese-American reproductive biologist Min Chueh Chang in 1959. Though he didn't fully understand it, Chang proves here that "oocytes fertilized in vitro were capable of developing and producing live normal young if transferred into the uterus" (Alberda, Pioneers in in vitro fertilization, 29). "For his experiment, Chang took sperm from male rabbits with specific traits not present in the female ovum donor." The presence of the male traits in the offspring provided unequivocal proof that the sperm had transmitted genetic information to the young" (Making Babies: Biomedical Technologies, 59). CONDITION & DETAILS: London: Macmillan and Co. Complete Volume 184. 4to. 10.5 by 7.5 inches (263 x 188mm). [4], clxxv, [482], 6. In-text illustrations throughout. Volume 184 has no library markings; Handsomely rebound in half-calf, gilt-lettered at the spine; tightly and very solidly bound. Five gilt-ruled raised bands at the spine; each compartment gilt tooled. Bright and clean throughout. Near fine condition in every way.