De Novorum Ossium, in Integris aut Maximis, ob Morbos, Deperditionibus, Regeneratione Experimenta..

Three folding engraved plates & one folding printed table. x, [11]-240 pp. 8vo, cont. vellum over boards (binding a little soiled & stained). Paris: F.A. Didot, 1775. First edition. Troja (1747-1827), studied medicine at Naples and in 1774 he went to Paris where he began the research on the formation of bone tissue and bone generation which made him famous. Although Réaumur and Trembley had earlier demonstrated the regrowth of limbs in crustacea and polyps, no one before had considered the possibility of regrowth of bones. "Troja demonstrated that if a foreign body is introduced into the marrow cavity of a long bone, the bony cylinder dies and a new bone is formed all around the necrotic one, the latter being eventually eliminated. Accordingly, Troja suggested that in treating extensive caries of the bone, marrow should be destroyed, so that new bone formation would result."-Leonardo, Lives of Master Surgeons, p. 428. Troja later took up again his work on bone surgery and regeneration. In 1814 he first described the perforating connective-tissue fibers, usually known as "Sharpey's fibers." Fine crisp copy. Ex Bibliotheca Mechanica. ❧ D.S.B., XIII, pp. 464-65. Hirsch, V, p. 642-"a very important work" (in trans.).