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Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways,
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Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing Hardcover - 2011 - 2012th Edition

by Jeffrey E. Green (Editor); Thomas Ried (Editor)


From the rear cover

Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors. This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer. These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers. State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented. Mouse-human comparisons of tumor pathologies are exemplified. Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed. The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer.

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  • Title Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing
  • Author Jeffrey E. Green (Editor); Thomas Ried (Editor)
  • Binding Hardcover
  • Edition number 2012th
  • Edition 2012
  • Pages 632
  • Volumes 1
  • Language ENG
  • Publisher Springer
  • Date 2011-12-08
  • Illustrated Yes
  • Features Bibliography, Illustrated, Index
  • ISBN 9780387698038 / 0387698035
  • Weight 2.15 lbs (0.98 kg)
  • Dimensions 9.2 x 6.1 x 1.5 in (23.37 x 15.49 x 3.81 cm)
  • Library of Congress subjects Transgenic mice, Mice as laboratory animals
  • Library of Congress Catalog Number 2011939084
  • Dewey Decimal Code 573.44
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Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and...

Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing

by Jeffrey E. Green & Thomas Ried (editors)

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New York: Springer, 2012. Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.. 1st Edition. Hard Cover. Very Good/Picture Boards. 8vo - over 7¾" - 9¾" tall.
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Genetically Engineered Mice for Cancer Research: design, analysis, pathways, validation and...
Stock Photo: Cover May Be Different

Genetically Engineered Mice for Cancer Research: design, analysis, pathways, validation and pre-clinical testing

by Green, Jeffrey E. [Editor]; Ried, Thomas [Editor];

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Hardcover
ISBN 10 / ISBN 13
9780387698038 / 0387698035
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Springer. hardcover. New. 6x1x9. Brand New Book in Publishers original Sealing
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A$440.03
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