Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing Hardcover - 2011 - 2012th Edition
by Jeffrey E. Green (Editor); Thomas Ried (Editor)
From the rear cover
Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors. This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer. These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers. State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented. Mouse-human comparisons of tumor pathologies are exemplified. Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed. The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer.
Details
- Title Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing
- Author Jeffrey E. Green (Editor); Thomas Ried (Editor)
- Binding Hardcover
- Edition number 2012th
- Edition 2012
- Pages 632
- Volumes 1
- Language ENG
- Publisher Springer
- Date 2011-12-08
- Illustrated Yes
- Features Bibliography, Illustrated, Index
- ISBN 9780387698038 / 0387698035
- Weight 2.15 lbs (0.98 kg)
- Dimensions 9.2 x 6.1 x 1.5 in (23.37 x 15.49 x 3.81 cm)
- Library of Congress subjects Transgenic mice, Mice as laboratory animals
- Library of Congress Catalog Number 2011939084
- Dewey Decimal Code 573.44
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Genetically Engineered Mice for Cancer Research: Design, Analysis, Pathways, Validation and Pre-Clinical Testing
by Jeffrey E. Green & Thomas Ried (editors)
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Genetically Engineered Mice for Cancer Research: design, analysis, pathways, validation and pre-clinical testing
by Green, Jeffrey E. [Editor]; Ried, Thomas [Editor];
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