PHARMACOLOGY OF ANTIMUSCARINIC AGENTS

Boca Raton - New York - London - Tokyo: CRC Press, 1998. First Printing . Printed Coated Boards. Near Fine/No Jacket. 9 1/2" Tall. The recent progess in molecular pharmacology, including characterization of several distinct acetylcholinergic receptor subtypes, provided opportunities to develop many receptor subtype-specific parasympathetic blocking, antimuscarinic agents with "tailor-made" pharmacologic profiles for a particular therapeutic need. Unquestionably, these newer agents will gradually replace the older ones, including the naturally occurring alkaloids. However, in the continuing efforts of characterizing acetylcholinergic receptor subtypes and designing new, more selective and safe blocking agents for the different muscarinic receptors the enormous old data base of structure-activity information, obtained with atropine and with many other anti-muscarinic "blocking probes" will still remain indispensible." [History] The major topics are Mechanism and Site of Action of Antimuscarinic Agents; The Tropane Alkaloids; Semisynthetic Derivitives of Tropane Alkaloids and of Other Tropine Esters; Synthetic Antimuscarine Agents; Molecular Design of Antimuscarinic Agents; Drug Interactions; Clinical Pharmacology and Therapeutic Uses of Antimuscarinic Agents; and Toxicity of Atropine. 501 pages, with Introduction, tables, figures. References, and Index; plus about 16 unnumber pages prefatory matter. Boards are clean and sound; text is clean, strong, and likely unread.