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Tumor Suppressor Genes in Human Cancer Hardback - 2000
by David E. Fisher (Editor)
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From the publisher
First line
The observation that bilateral retinoblastoma (RB) occured with earlier onset than unilateral disease led Knudson to formulate the two-hit theory for tumorigenesis (1).
From the rear cover
While the war against cancer has seen great advances in our understanding of cell proliferation and its regulation at the molecular level, the translation of this knowledge into effective therapies has lagged well behind. In Tumor Suppressor Genes in Human Cancer, David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Additional coverage is accorded animal models, viral oncoproteins as probes, and cancer metastasis. An extensive chapter on cancer drug discovery is provided to help integrate the new molecular oncology with technologies which fuel the pragmatic search for improved cancer therapeutics.
Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.
Details
- Title Tumor Suppressor Genes in Human Cancer
- Author David E. Fisher (Editor)
- Binding Hardback
- Edition U. S. EDITION
- Pages 386
- Volumes 1
- Language ENG
- Publisher Humana
- Publication date 2000-10-26
- Illustrated Yes
- Features Bibliography, Illustrated, Index
- ISBN 9780896038073 / 0896038076
- Weight 2.02 lbs (0.92 kg)
- Dimensions 10 x 7 x 0.94 in (25.40 x 17.78 x 2.39 cm)
- Category Medical / Nursing
- Library of Congress subjects Neoplasms - genetics, Antioncogenes
- Library of Congress Catalogue Number 00027593
- Dewey Decimal Code 616.994
Media reviews
Citations
- Scitech Book News, 03/01/2001, Page 88
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