Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observatio Hardback - 2015
by Iman Tavassoly
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From the publisher
From the rear cover
This interdisciplinary thesis introduces a systems biology approach to study the cell fate decision mediated by autophagy. A mathematical model of interaction between Autophagy and Apoptosis in mammalian cells is proposed. In this dynamic model autophagy acts as a gradual response to stress (Rheostat) that delays the initiation of bistable switch of apoptosis to give the cells an opportunity to survive. The author shows that his dynamical model is consistent with existing quantitative measurements of time courses of autophagic responses to cisplatin treatment. To understand the function of this response in cancer cells, he has provided a systems biology experimental framework to study quantitative and dynamical aspects of autophagy in single cancer cells using live-cell imaging and quantitative fluorescence microscopy. This framework can provide new insights on function of autophagic response in cancer cells.
Details
- Title Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells: Mathematical Modeling and Experimental Observatio
- Author Iman Tavassoly
- Binding Hardback
- Pages 79
- Volumes 1
- Language ENG
- Publisher Springer
- Publication date 2015-03-25
- Features Bibliography
- ISBN 9783319149615 / 331914961X
- Weight 0.72 lbs (0.33 kg)
- Dimensions 9.21 x 6.14 x 0.31 in (23.39 x 15.60 x 0.79 cm)
-
Themes
- Aspects (Academic): Science/Technology Aspects
- Category Technology & Industrial Arts
- Dewey Decimal Code 570.285
About the author
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Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells : Mathematical Modeling and Experimental Observations
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